Product Name :
RGMA Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
Repulsive guidance molecule A antibody RGM antibody RGM domain family member A antibody RGMA antibody RGMA_HUMAN antibody
Function :
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition.2-Chloro-6-fluoro-1H-benzo[d]imidazole uses Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway.Formula of (4-(3-Hydroxypropyl)phenyl)boronic acid It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.PMID:33393408
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Recombinant protein within human RGMA aa 169-424.
Species reactivity:
Human
Verify application:
WB, IHC-P, IF-Cell
Coupling :
unconjugated
Clone number:
RRID:
AB_3071246
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 50 kDa
Positive control :
Hela cell lysate, human skeletal muscle tissue lysate, MG-63, human skeletal muscle tissue.