Product Name :
SATB1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
DNA binding protein SATB1 antibody DNA-binding protein SATB1 antibody SATB homeobox 1 antibody SATB1 antibody SATB1_HUMAN antibody Special AT rich sequence binding protein 1 (binds to nuclear matrix/scaffold associating DNA) antibody Special AT rich sequence binding protein 1 antibody Special AT-rich sequence-binding protein 1 antibody
Function :
The homeoproteins CCAAT displacement protein (CDP) and special AT-rich sequence binding protein 1 (SATB1) are transcriptional repressors of many cellular genes, and they participate in cell development and cell type differentiation. SATB1 is expressed primarily in thymocytes, and, like CDP, it also contains a distinct homeobox DNA-binding domain that is essential for DNA binding. SATB1 and CDP interact through these homeodomains and synergistically function as mediators of gene expression. SATB1 contains an additional domain that has a higher affinity for DNA and specifically facilitates the direct association between SATB1 and the nuclear matrix attachment regions (MARs) of DNA. MARs are specific DNA sequences that bind to the nuclear matrix and form the base of chromosomal loops that organize the chromosomes and regulate DNA transcription and replication within the nucleus.1234616-70-6 Chemscene The association of SATB1 with the core unwinding element within the base-unpairing region of MARs requires both the MAR and homeobox binding domains of SATB1.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within N-terminal human SATB1 aa.
Species reactivity:
Human, Mouse
Verify application:
WB, IF-Cell, FC
Coupling :
unconjugated
Clone number:
RRID:
AB_3069122
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.2,2-Dimethyl-morpholine web Aliquot store at -20℃ or -80℃.PMID:33400671 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size 86 kDa
Positive control :
Mouse thymus tissue lysate,SH-SY-5Y, Jurkat.