Product Name :
SETD7 Mouse Monoclonal Antibody [1B3B8]
Predicted band size :
Observed band size :
Synonyms:
FLJ21193 antibody H3 K4 HMTase antibody H3-K4-HMTase SETD7 antibody H4 lysine 4 specific antibody Histone H3 K4 methyltransferase antibody Histone H3 lysine 4 specific methyltransferase antibody Histone H3-K4 methyltransferase SETD7 antibody Histone H4 K4 methyltransferase antibody Histone lysine N methyltransferase antibody Histone lysine N methyltransferase H3 lysine 4 specific SET7 antibody 展开
Function :
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3.Buy[2,2′-Bipyridine]-5,5′-dicarboxaldehyde H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription.Price of Pyrimidine-2-carbaldehyde Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins.PMID:33661213 Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Purified recombinant fragment of human SETD7 (AA: 107-366) expressed in E. Coli.
Species reactivity:
Human, Rat, Monkey
Verify application:
WB, FC
Coupling :
unconjugated
Clone number:
1B3B8
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
4℃; -20℃ for long term storage.
Storage buffer solution:
Purified antibody in PBS with 0.05% sodium azide.
Subtype:
IgG2a
Purification method :
Protein G affinity purified.
ELTSA :
Molecular weight :
40.7kDa
Positive control :
MCF-7, Hela, A549, COS7, Jurkat, and PC-12 cell lysate, Hela cells