Product Name :
SREBP1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
ADD 1 antibody bHLHd1 antibody Class D basic helix-loop-helix protein 1 antibody D630008H06 antibody Processed sterol regulatory element-binding protein 1 antibody SRBP1_HUMAN antibody SREBF 1 antibody SREBF1 antibody SREBP 1 antibody SREBP 1c antibody 展开
Function :
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human SREBP-1 301-450/1147
Species reactivity:
Human, Mouse, Rat, Chicken, Sheep
Verify application:
WB, ELISA, IHC-P, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year.Price of Methyl 5-formylpicolinate Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.2,4-Dichloro-5-nitropyrimidine custom synthesis When reconstituted in sterile pH 7.PMID:33728495 4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
122 KDa
Positive control :
Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines.