Product Name :
TAZ Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
DKFZP586I1419 antibody FLJ27004 antibody FLJ45718 antibody OTTHUMP00000215994 antibody OTTHUMP00000215995 antibody OTTHUMP00000215996 antibody OTTHUMP00000216001 antibody TAZ antibody Transcriptional co activator with PDZ binding motif antibody Transcriptional coactivator with PDZ binding motif antibody 展开
Function :
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human TAZ 1-100/400
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, ELISA, IHC-P, FC, IF, ICC
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.1,1′-(1,3-Phenylene)diethanone Formula 4 0.Price of 2,5-Dibromo-4-fluoropyridine 01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.PMID:33676863
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
44 KDa
Positive control :
Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue.